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KMID : 0368819920310050846
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Journal of the Korean Neuropsychiatr Association
1992 Volume.31 No. 5 p.846 ~ p.855
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The Effect of Electroconvulsive Therapy on the Cerebrospinal Fluid 5-HT and 5-HIAA Concentrations in the Chronic Treatment-Resistant Schizophrenia
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Abstract
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The effect of a series of ECT treatments on the CSF 5-HT and 5-HIAA concentrations was studied in the 10 patients suffering from chronic treatment-resistant schizophrenia. The clinical improvement of the patients was assessed with BPRS weekly.
Total BPRS scores significantiy decreased after a series of ECT treatment, And positive negative, thinking disturbance, withdrawal/retardation and hostility/suspiciousness symptom subscale scores were also decreased significantly after ECT
treatment,
But anxiety/depression symptom subscale did not show statistically significant change.
The CSF 5-HT concentrations significantly decreased after a series of ECTs. But the CSF 5-HIAA concentrations showed a trend to decrease which was not statistically significant.
Percentile improvement on total BPRS score was positively correlated with pre-ECT concentration of CSF 5-HT showed the better clinical improvement. And percentile improvement on total BPRS scores showed significant negative correlation with
change
in
the concentration of 5-HT after ECT treatments.
These results suggest that ECT may be effective in the treatment of treatment-resistant chornic schizophrenia and, although it's mechanism is still unknown, may affect the central serotonergic system in schizophrenics, which may be related to the
clinical improvement after a series of ECTs.
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KEYWORD
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